I'm going to back up a little bit on this thread, which I really started with the intention of dealing primarily with the old "loose raiser" problem, but I wanted to be a little more comprehensive and hence started with some tight-os.
Anyhow, I think the first thing to look at is just the question of excessive vs. moderate raises. If the raise is excessive, I think you be pretty cautious about calling with anything where you don't have a high probability of already being ahead. AK imo is bad here, QQ and JJ get more interesting. On those as overpairs (or sets), you put a lot of pressure on your raiser if you put a power play on him. With JJ, of course, you're actually probably behind if the raiser is tight. But that's a bluff that I think is tenable (due to its rarity). I just can't bring myself to put $650 out there as bluff while holding 88 to overcards against any good opponent. With JJ, if you do want to pound it from behind, you at least are working with a 50% probability of having an overpair on the flop. This is a player where you may also not want to re-raise AA but rather give them a free flop because the continuation bet is going to be sweet due to the excessive raise (then again, if they're tight and have as much as $50 out there in a 2/5 game, I don't know whether they'll lay down QQ if you make it $150 to go).
If the raise is kind of "in between," like $35, the decision of trying to set, I think, is going to have to do with how multi-way the pot is. If the guy can lay down and it's likely HU, I think just much one's 22.
But the second, extremely important distinction here is between action raisers and what one might call weak raisers. The action raiser is someone who certainly can't lay down AA and may pursue unimproved AQ for full stack (there are plenty of these guys). THOSE are the players you want to set against.
It's also worth noting that this distinction is still completely independent of hand selection for the raiser. A lot of loose raisers may throw a little bit at the pot with AXo after raising, but then they lay down. So, setting is pointless. But if they'll play for full stack on hitting their X or their A, then you can be all about setting.
To be continued...

Hopefully with more good feedback in the interim...